Picking up where the finale left off, Dean and Sam watch as the Devil emerges from Hell. The brothers and Bobby deal with the aftermath of Lucifer rising and the stunning news from Chuck the Prophet that Castiel was blown to bits by the archangels.

Castiel tells Sam and Dean that he is going to search for God, who will be able to defeat Lucifer. Bobby, 's old hunter friend, Rufus, is panicked about demons attacking his town, and begs Bobby for help. Sam and Dean arrive at the town and realize there is a spell over the townspeople, making them hallucinate that they are demons and causing them to kill one another.

Not sure he trusts himself anymore, Sam decides to give up hunting, but a late-night visitor won, 't let him off the hook that easily. Dean, intent on stopping the Apocalypse, continues hunting on his own and teams up with Castiel to find the Archangel Raphael, as Castiel believes Raphael knows God, 's location.

In the fourth episode of season four (s5e4) of TV show ‘SUPERNATURAL’, Sam is eager to rejoin Dean in his mission but Dean rejects his proposal. Later, Dean is transported in the future, five years ahead. He finds himself in an abandoned city where the demons have infected the people and turned them into Zombies.

In the fifth episode of season four (s5e5) of TV show ‘SUPERNATURAL’, the Winchesters join hands to again start hunting together. They encounter a strange case where the people of a town were murdered by famous people who are now dead. But the case takes a different direction when Paris Hilton is said to have abducted a girl.

Sam and Dean investigate a series of murders that echo fairy tales and urban legends. Their probe leads them to an 11-year-old boy who's able to make everything he believes come true. Castiel thinks the lad is a threat and wants him eliminated.

Sam and Dean discover a witch is running a high-stakes poker game where the currency is life years vs. money. Bobby sees the game as a chance to get out of the wheelchair and bets 25 years, but loses. As Bobby begins to age rapidly, Dean steps in to save him but also ends up turning into an old man, leaving Sam holding the bag for their survival.

Dean and Sam find themselves mystically trapped in a series of real-life "TV shows" and there appears to be no escape. They believe their old enemy the Trickster is responsible, but discover someone or something else is involved...

Sam and Dean are tricked into attending a Supernatural convention by their super-fan Becky. Sam and Dean are in for a shock when many of the fans are dressed up like them....

Sam Dean, and Castiel track down the Colt and head off to find Lucifer to send him back to Hell. It, 's a hunters, ' reunion when the crew joins forces with Bobby, Ellen, and Jo for what could be their last night on Earth.

Sam and Dean investigate a series of deaths at a mental hospital caused by a supernatural force. The only way they can get in is to go undercover as patients, and they soon discover they have some issues to work out. '

Gary, a teenage nerd, conjures up a body switching spell and changes bodies with Sam. Thrilled by his new handsome and built body, Gary (now Sam) investigates a case with Dean and takes advantage of his good looks and age by hitting on women and getting drunk. Meanwhile, Sam is stuck in Gary's teenage body, dealing with intrusive parents and high school.

Anna is sent back in time to kill Mary and John Winchester before Sam is conceived.

Castiel helps Sam and Dean hunt down Cupid on Valentine's Day after townspeople start to kill each other for love. However, after Cupid tells them he's innocent, they discover Famine, one of the Four Horsemen of the Apocalypse, has arrived in town.

Sam and Dean investigate Bobby's home town where the dead are rising from the grave but instead of attacking humans, they are happily reuniting with their families. The brothers turn to Bobby for help but he tells them not to worry about it and to leave town. Suspicious, Dean investigates and comes face to face with Bobby's dead wife, who has no memory of what happened to her. Once the zombies start turning evil, the boys tell Bobby he has to kill his wife but he refuses.

Ambushed by angry hunters, Sam and Dean are shot and killed and sent to Heaven. Castiel warns Dean that Zachariah is looking for them in Heaven so they need to lay low while searching for an angel named Joshua who can help them since he talks directly to God. While searching for Joshua, the brothers run into some old friends and family members.

Sam and Dean are outnumbered by demons, but are saved at the last minute by Rob and his townspeople, who are aware of the Apocalypse, and have been training to fight and kill demons. The small town is very religious and Sam and Dean meet Pastor Gideon, who introduces them to his daughter Leah, whom he claims is a prophet. Leah tells the townspeople they must obey her orders if they want a spot in Heaven but when she starts turning the townspeople against each other in the name of the Lord, the brothers realize they must kill her.

Dean begins to think the only way to stop Lucifer is to say yes to Michael, but the angels decide they don't need him anymore. Dean, Sam, and Castiel are horrified at the angels' new game plan and take on Zachariah to prevent an all out war on Earth. Meanwhile, a familiar face returns.

Sam and Dean are kidnapped by a group of gods, including Kali, Ganesh, and Bladur and held hostage in a small hotel. The gods want to use Sam and Dean as bargaining chips to stop the Apocalypse, but Gabriel shows up and warns them that if Lucifer finds them he will kill them all. Unfortunately, one of the gods turns on the rest and Lucifer appears.

The demon Crowley tells Sam and Dean he can help them find the remaining Horsemen rings so they can trap Lucifer. The brothers are doubtful until Crowley leads them to Brady, the Handler for Pestilence and Death. However, Brady refuses to give up their locations and sets Pestilence after the Winchesters.

Crowley tells Bobby he will give him the location of Death, the fourth horseman, in exchange for his soul. Knowing Sam and Dean need that fourth ring to stop the Apocalypse, Bobby reluctantly agrees. Sam and Dean confront Pestilence, but he unleashes a deadly virus upon them, so Castiel must intervene on their behalf. Dean has a meeting with Death to discuss Lucifer, and an unholy alliance is formed at a very high price for Dean.

When the Winchesters run out of options, Sam decides that he must open himself to Lucifer and hope that he can maintain control long enough to seal Lucifer away. However, he soon discovers that he is in over his head, and his brother and friends must pay the price.