After the opening of the hell’s gates, the seven demons play havoc and start killing people in the first episode of season three (s3e1) of TV show ‘SUPERNATURAL’. Sam and Dean helped by fellow hunters, Tamara and Issac go on to fight with the demons when a strange woman with a mystic knife appears before them.

Sam and Dean go after demons targeting mothers and their children. While on the hunt, Dean runs into Lisa, a woman from his past, who has a son that reminds Dean of himself at that age. The son, Ben, soon goes missing and Dean and Sam uncover that a Changeling is kidnapping kids from the small town and taking over their form. Meanwhile, Ruby meets up with Sam and reveals startling information about his mother.

Sam and Dean receive a call on their father's cell phone telling them that someone has broken into John's storage room in New York. There, they find that a cursed rabbit's foot has been stolen and call their old friend Bobby for help. Bobby tells them that whoever has touched the foot will have good luck until they lose the foot, which will result in the person dying. Since Sam has touch the foot, Dean buys lottery tickets, but when a thief steals it, Sam's life is in danger.

Sam and Dean investigate a series of murders in Elizabethville in Ohio in the fourth episode of season three (s3e4) of TV show ‘SUPERNATURAL’. A similarity is found in the execution of the all the killings. The brothers also find out that the demons are the reason for the gruesome killings and decide to use the colt.

A girl whom is trapped in a coma by her wicked stepmother starts a chain of murders based on fairy tales her father reads her. Meanwhile Sam tries to get Dean out of his deal.

In the sixth episode of season three (s3e6) of TV show ‘SUPERNATURAL’, the brothers investigate a case of drowning in which people claimed to have seen a strange ghostly ship just before their death. They drowned without going inside the water. The brothers also meet Bela, the girl who is also looking into the case.

Sam and Dean capture Lucy, a female vampire, who has no knowledge of how she became a vampire. The brothers come across Dixon, a male vampire, who gives blood to females he meets in bars, telling them it's the hottest new drug. Meanwhile, after escaping from prison, Gordon sets out to find Sam, but when Dixon intercepts him and turns him into a vampire, Gordon is now an even bigger threat to Sam.

It's Christmas and Sam and Dean look into the murders of people who were pulled through their chimney. While investigating, Sam learns that they are dealing with an Anti-Santa, a demon that has roots in pagan lore. When Dean wants to have an old-fashioned Christmas, Sam has flashbacks to a Christmas where he waited for his father to come home with one special gift.

A neighborhood group of witches secretly practice harmless rituals... until one of them kills another neighbor woman.

Sam and Dean have to help their friend Bobby who has been declared by the doctor to be in a state of coma in the tenth episode of season three (s3e10) of TV show ‘SUPERNATURAL’. The brothers find out that it is the work of a demon who is capable of entering people’s dream , trap them and kill them ultimately.

Dean dies when the owner of a place shoots him when the two brothers try to break into his place for some investigation purpose in the eleventh episode of season three (s3e11) of TV show ‘SUPERNATURAL’. Next day, Sam finds Dean alive. But he realizes later that he is living that day again and again.

Sam and Dean break into Bela's apartment to find the Colt, but Agent Henricksen is on the scene and arrests them both on the spot. While Sam and Dean are locked up in a jail in Colorado, a demon breaks in, kills the police, and possesses Henricksen. After the brothers do away with the demon, the FBI release release them, only to learn from Ruby that the jailhouse is surrounded by demons who want Sam dead.

Sam and Dean end up appearing on Ghostfacers, a reality TV show created by ghost hunters Ed Zeddmore and Harry Spengler. They all find themselves at the Morton Mansion where every year someone mysteriously disappears never to be seen again. Now the brothers must protect the Ghostfacers and defeat the ghost.

Sam and Dean take on a being that uses phones and computers to cause people to commit suicide so it can claim their souls.

The guys go after a doctor who has discovered the secret of maintaining his life as long as he takes other people's organ. Meanwhile, Dean goes to confront Bela and recover the Colt.

It's 30 hours before Dean's deal with the crossroads demon is up and Dean, Sam and Bobby are searching for Lilith, who holds the contract. They discover her location and Sam summons Ruby for help despite Dean's protests. Ruby warns them they aren't ready to fight Lilith yet but they steal her knife and depart for New Harmony, Indiana. In a battle to the death, Sam, Dean and Bobby take on Lilith and all her demons in a last ditch effort to save Dean's life.